交易须知
laquinimod产品活性：laquinimod是一种有效的免疫调节剂，可预防中枢神经系统的神经变性和炎症。
研究领域：nf-κb
作用靶点：nf-κb
in vitro: laquinimod reverses eae and inhibits pathogenic t cell immune responses. laquinimod reverses rr-eae and inhibits inflammatory t cell responses via a direct effect on myeloid apc. laquinimod alters myeloid apc subsets and inhibits th1 and th17 polarization of myelin-specific t cells. laquinimod-induced type ii (m2) monocytes reverse established eae. laquinimod modulates the phenotype of b cells of healthy donors. laquinimod modulates expression of markers related to regulatory capacity in b cells of rrms patients. laquinimod reduces ifnγ cytokine expression in cd4+ t cells.
in vivo: laquinimod treatment inhibits donor myelin-specific t cells from transferring eae to naive recipient mice. in vivo laquinimod treatment alters subpopulations of myeloid antigen presenting cells (apc) that include a decrease in cd11c+cd11b+cd4+ dendritic cells (dc) and an elevation of cd11bhigr1hi monocytes.
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